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EGFR Test - Purpose, Low High Normal Range, Full Form, Price

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Medically Reviewed by Dr. Aman Priya Khanna
Written by Rajath R Prabhu, last updated on 13 March 2023| min read
EGFR Test - Purpose, Low High Normal Range, Full Form, Price

Quick Summary

  • Kidneys are one of the most crucial organs that play a vital role in purifying one's blood. It is imperative to ensure their effective functioning to avoid the chances of fatal health conditions.
  • eGFR enables healthcare providers to gauge the functioning of one's kidneys. It measures the amount of blood that is filtered by the kidneys per minute, depending on the body's surface.
  • The eGFR blood test provides insights into the condition of the kidneys, allowing doctors to spot possible diseases early on

Kidneys are one of the most crucial organs that play a vital role in purifying one's blood. It is imperative to ensure their effective functioning to avoid the chances of fatal health conditions. However, many people are able to identify kidney-related diseases much later on when the kidneys have significantly deteriorated. This is where a dedicated eGFR test can help.

Known as the estimated glomerular filtration rate, eGFR enables healthcare providers to gauge the functioning of one's kidneys. It measures the amount of blood that is filtered by the kidneys per minute, depending on the body's surface. The eGFR blood test provides insights into the condition of the kidneys, allowing doctors to spot possible diseases early on

What is the Estimated Glomerular Filtration Rate (eGFR)?

A kidney contains glomeruli which are tiny filters that assist in removing toxins and other wastes from the blood. The estimated glomerular filtration rate test shows the functioning of these glomeruli. Healthy individuals often have higher numbers on the eGFR test, while patients with kidney diseases have low eGFR. 

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Need for eGFR Test

In most cases, symptoms of kidney diseases and failures are visible only when 30 to 40% of the kidneys have stopped functioning. This further leads to complicated health conditions and results in severe kidney deterioration. 

Opting for an estimated glomerular filtration rate test can help identify issues in the kidney functioning early on, allowing the doctors to treat the patient towards the prevention of kidney failures. Some of the key purposes of eGFR include the following:

  1. Early detection and monitoring of kidney disease: eGFR can help identify early signs of kidney disease before symptoms occur, allowing for early intervention and management.
  2. Assessment of kidney function: eGFR can help assess the severity and progression of kidney disease, as well as monitor the effects of treatment.
  3. Adjustment of medication dosages: Certain medications are cleared from the body by the kidneys, and eGFR can help determine appropriate dosages to prevent toxicity.
  4. Risk assessment: Low eGFR values are associated with an increased risk of adverse health outcomes such as cardiovascular disease, so monitoring eGFR can help identify individuals at higher risk.

eGFR Test Normal Range

The eGFR blood test normal range is typically between 90 to 120 mL/min/1.73 m2. However, this range can vary depending on age, sex, and other factors, and individual results should be interpreted in the context of the individual's medical history and other clinical information.

Low eGFR Blood Test: Causes

A low eGFR blood test result indicates that the kidneys may not be functioning optimally. There are several possible causes of a low eGFR, including:

  1. Chronic kidney disease (CKD)
  2. Diabetes
  3. High blood pressure
  4. Autoimmune disorders such as lupus
  5. Kidney infections or inflammation
  6. Polycystic kidney disease
  7. Congenital kidney abnormalities
  8. Certain medications or toxins
  9. Dehydration

High eGFR Blood Test: Causes

A eGFR blood test high result indicates that the kidneys may be functioning at a higher than the normal rate. There are several possible causes of a high eGFR, including:

  1. Pregnancy
  2. Obstruction of the urinary tract
  3. Kidney infection
  4. Certain medications or supplements that increase blood flow to the kidneys
  5. Overhydration or excess fluid intake
  6. Vigorous exercise before the test

Preparations for eGFR Test

Preparing for an eGFR test involves a few simple steps to ensure accurate results. Some important preparations for an eGFR test include:

  1. Fasting: Depending on the specific test ordered, fasting may be required for a certain amount of time before the test. Follow any instructions provided by your healthcare provider.
  2. Medications: Some medications can affect eGFR results, so inform your healthcare provider of any medications you are taking before the test.
  3. Hydration: Adequate hydration is important for accurate eGFR results, so be sure to drink plenty of fluids before the test.
  4. Time of day: eGFR levels can fluctuate throughout the day, so it is often recommended to have the test performed at the same time of day for consistency.
  5. Other factors: Avoid strenuous exercise or activities that may cause dehydration or affect kidney function before the test.

Following any instructions provided by your healthcare provider and staying hydrated can help ensure accurate eGFR test results.

How is The eGFR Test Performed?

Human bodies make and consume a chemical called creatine that provides energy to the muscles. The muscle tissues tend to break down after using the energy and release a toxin known as creatinine into the blood. 

The kidneys filter out this toxin from one's blood and excrete it from the body with urine. Since the accurate GFR test is extremely complex and is opted for only in the case of kidney transplants, most healthcare providers leverage a formula to get an estimated GFR measure. 

To get this estimated rate, doctors use a serum creatinine blood test and consider factors like age, sex and weight to determine the correct number. The serum creatinine blood test is helpful in indicating the amount of creatinine in one's blood. 

As the test is extremely sensitive, patients must strictly adhere to the guidelines shared by doctors in order to achieve as accurate results as possible. This can include fasting for one day, being on a liquid diet, or preventing specific medications. 

The test is typically performed in a clinical laboratory setting and involves the following steps:

  1. The healthcare provider will typically ask about any medications, supplements, or health conditions that may affect the test results.
  2. The healthcare provider will clean the area of the arm where the blood will be drawn with an antiseptic solution.
  3. A small needle is inserted into a vein in the arm, and blood is drawn into a collection tube.
  4. The needle is removed, and pressure is applied to the site to stop any bleeding.
  5. The blood sample is sent to a laboratory for analysis.
  6. The laboratory will use a mathematical formula that takes into account the person's age, sex, and race to estimate the eGFR.
  7. The laboratory may also test for other substances in the blood, such as creatinine and blood urea nitrogen (BUN), which can provide additional information about kidney function.
  8. Results are typically reported in mL/min/1.73 m², which is a measure of how much blood the kidneys can filter per minute per square meter of body surface area.

What to Expect After The eGFR Test?

After an eGFR test, patients can generally resume their normal activities. There are typically no restrictions on diet or exercise after the test. However, patients may experience mild discomfort or bruising at the site of the needle stick, which should resolve within a few days. 

It is important to follow up with the healthcare provider to discuss the results of the eGFR test and any next steps, such as additional testing or treatment, if necessary. If the eGFR test results indicate an underlying kidney disease or other health condition, the healthcare provider may recommend changes to diet, medications, or other lifestyle factors to help manage the condition.

Interpretation of eGFR Test Report

Different stages of kidney disease can be determined based on the measure given by the eGFR test. The following table takes a closer look at the individual test readings and their indications. 

Stage

eGFR Number

Indication

Stage 1 eGFR of 90 or higher Kidney are functioning well but can have mild damage
Stage 2 eGFR between 60 and 89 Kidneys work well but shows increase in kidney damage from the initial state
Stage 3 eGFR between 30 and 59 Onset of symptoms due to kidney damage with decreased functioning
Stage 4 eGFR between 15 and 29 Alarming state showing moderate kidney damage with poor functioning
Stage 5 eGFR below 15 Indicates kidney failure and can be fatal if not opted for dialysis or transplant

Factors That Affect The eGFR Test

It is interesting to note that the results of the eGFR blood test tend to vary, depending on certain factors. These often influence the estimated rate at which one's kidneys purify the blood. Below are the most highlighted factors that impact the eGFR test results:

  1. Diabetes: High blood sugar in diabetic patients comes in the way of the functions performed by the small blood vessels in one's kidneys. This severely impacts the effectiveness of kidneys and tends to produce low numbers on the eGFR test. 
  2. Obesity: Being overweight can hamper multiple organs' functioning, and kidneys are one of them. Patients with obesity also carry a risk of possible kidney diseases, and a dedicated eGFR examination can indicate the onset of the condition. 
  3. Age: The measure of eGFR tends to dip with age. It is often a lower number for patients over the age of 60 and above. This is why most aged people struggle with kidney diseases. 
  4. High Blood Pressure: Patients with high blood pressure often stand at risk of severe kidney diseases. This is likely to be reflected in the eGFR test and help providers identify the stage at which the kidneys are functioning. 

Conducting the estimated glomerular filtration rate test along with regular body checkups is vital to spot the development of kidney diseases at an early stage. Based on this, doctors can plan necessary treatment to slow down or prevent further damage to the kidneys. Failing to do so can have severe outcomes, leading the patient to the path of dialysis or kidney transplant. 

Table: Establishing the different stages of kidney diseases based on eGFR number

eGFR Test Cost

The eGFR blood test is not an expensive test in India. It usually costs around ₹ 350 and provides you with credible results. However, the GFR test can be complicated and expensive. Based on the eGFR number, one must plan the further course of action and take necessary consultation to prevent the kidney disease from spreading. 

The eGFR test cost can vary depending on a number of factors. Some of the factors that can affect the cost of the test include:

  1. Location: The cost of the test can vary depending on the geographic location of the laboratory or healthcare facility where the test is performed.
  2. Health insurance: The cost of the test may be covered by health insurance, which can help reduce out-of-pocket costs for patients. However, the specific coverage and cost-sharing requirements may vary depending on the patient's insurance plan.
  3. Additional tests: Depending on the healthcare provider's recommendation, additional tests may be performed along with the eGFR test, which can increase the overall cost.
  4. Laboratory fees: The laboratory that performs the eGFR test may charge a fee for the test, which can vary depending on the specific laboratory and location.
  5. Provider fees: In addition to the laboratory fees, healthcare providers may charge a fee for performing the test or for interpreting the results.

Takeaway

Kidney damage can become a life-threatening condition, and thus, it is essential to identify the onset of the disease early on. The eGFR blood test can help get an indicative measure of your kidney functions and spot possible degrees of damage to the organ. 

Based on the eGFR number, you can consult with the doctor to decide on the next step for dedicated treatment. An extremely low number may indicate severe kidney failure and call for an immediate transplant as well. 

Our professionals at HexaHealth understand your specific concerns and serve you with a seamless experience for getting medical tests done with ease. We ensure complete hygiene and provide accurate results to lead you the right way. Speak to our expert teams and take your first step towards achieving a healthy body. 

Frequently Asked Questions

The eGFR test is the estimated glomerular filtration rate test that measures the amount of blood purified by your kidneys in a minute based on your body size. A higher number on the test indicates healthy functioning of the kidneys, while a lower number shows the extent of kidney damage.

The eGFR blood test stands for the estimated glomerular filtration rate. It establishes the effectiveness of glomeruli which are tiny fibres present in your kidneys. 

The eGFR test is used to gauge the functioning of your kidneys and identify the onset of possible kidney disease. Based on the eGFR number, doctors can determine the stage at which your kidneys are working. 

The eGFR test gives an estimated measure of how much blood your kidneys are purifying each minute, depending on the body's surface. Damaged kidneys fail to function well and result in a lower eGFR number. 

Doctors give an eGFR number based on the formula calculation that uses the serum creatinine blood test along with other crucial factors like age and gender. The serum creatinine blood test is conducted on a blood sample in the laboratory and gives the measure of the creatinine in your blood. 

While opting for an eGFR test, your doctor may advise fasting for one day before the sample is collected. You may also be asked to shift to a liquid diet since the creatinine blood test is extremely sensitive and may give inaccurate results if you eat specific foods before the test. 

The eGFR levels are best checked through your blood sample. It gives an indicative measure of how much toxins are present in your blood alongside considering your gender, age, weight and other factors. 

After giving the eGFR test, it may take a few days before you get the exact laboratory reports for the test results. The formula for calculating the eGFR number may vary in some laboratories. 

An eGFR number between the range of 90 to 120 mL/min/1.73 m2 is considered a normal range, indicating healthy kidney functioning. However, the condition becomes alarming as the test numbers go down. 

The eGFR blood test is considered high if the number falls between 90 to 120 mL/min/1.73 m2. On the other hand, having an eGFR number of 60 or less for three months continuously can indicate a kidney infection. 

A higher eGFR number indicates better functioning of your kidneys. A test result of 60 mL/min/1.73 m2 shows that over 60% of your kidneys are working well. 

A lower eGFR blood test number indicates the degree of your kidney damage. As the number goes down, the higher the amount of kidney damage. A test result of 15 mL/min/1.73 m2 is a life-threatening state that calls for a kidney transplant. 

The eGFR mutation test is often a complex examination and can be slightly expensive. The test in most laboratories costs over ₹ 6.000 to ₹ 8,000 but provides accurate results for further consideration. 

It can be a cause of worry if your eGFR test number is lower than the normal range. You can consult with your doctor based on the test results and plan for the next course of action. 

A higher eGFR number is considered good as it indicates the healthy functioning of your kidneys. On the other hand, a lower eGFR number shows poor kidney condition and indicates the onset of possible kidney diseases. 

Low eGFR test results arising from acute kidney injuries can be reversed with effective treatment. However, chronic kidney diseases can only be impacted with positive lifestyle changes, which can slow down kidney damage. 

Maintaining a specific diet can help bring down high eGFR levels. Avoiding processed foods and increasing the consumption of fruits can help improve the condition. For patients with high blood pressure, reducing salt intake can also help. 

Your eGFR number can get better with an improved diet and regular exercise. It is also advised to quit smoking while including lots of fruits and vegetables in your daily meals. 

Certain medical treatments can help improve low GFR numbers. You must also opt for a balanced diet with a very low amount of sodium to prevent further kidney damage. Exercising for a minimum of 30 minutes daily can further better your kidney functioning. 

Fruits and vegetables can be extremely effective in improving your GFR. Dark leafy greens, cabbage, berries and tomatoes can be extremely helpful in enhancing your kidney functions. 

Increasing the intake of water can help improve eGFR to a certain extent. It betters kidney functions and paves the way for a healthy system. 

Conditions like hypertension and diabetes can be significant contributors causing low eGFR. The eGFR number also tends to dip as you get older. Other reasons can be severe kidney damage or infections. 

Frequent cases of urinary tract infections, being overweight and having a habit of smoking can all cause a higher level of eGFR. People with high blood pressure may also get higher eGFR numbers in some cases. 

You must avoid foods that are high in sodium since they cause additional burdens to your kidneys. High-potassium foods, including bananas, oranges, and potatoes, should also be avoided during this time. Meat and fish, which are high in protein, can also put a strain on your kidneys and thus should be eaten in lesser quantities. 

In some cases, fasting can result in a slight drop in eGFR. This is also dependent on individual bodies as few people undergoing intermittent fasting have witnessed an increase in the eGFR as well.

Yes, lack of water is likely to impact the GFR number. This is because dehydration can cause the accumulation of creatinine in the blood, resulting in a lower number of GFR. 

Any number less than 15 mL/min per 1.73 m2 indicates the need for dialysis. It can be a life-threatening situation if you must opt for dedicated treatment at such a low eGFR number. 

Yes, a low eGFR number points towards possible kidney diseases. A significantly lesser number indicates kidney failure, requiring you to opt for dialysis or a transplant. 

The GRF tends to reduce with age as the kidney functions dip as you grow old. However, taking care of your diet and maintaining a regular exercise routine can slow down the process of kidney damage. 

The GFR measures the extent to which your kidneys function. A lower count evidently indicates possible kidney damage and helps you identify the onset of any severe diseases. 

Yes, higher amounts of creatinine in the blood indicate that your kidneys don't function well. This results in lower eGFR numbers and helps doctors spot the causes.

Urinalysis or further blood tests may be required to identify the underlying causes behind an abnormal eGFR. Your doctor will suggest a further path after analysing your eGFR results in detail.

Last Updated on: 13 March 2023

Disclaimer: The information provided here is for educational and learning purposes only. It doesn't cover every medical condition and might not be relevant to your personal situation. This information isn't medical advice, isn't meant for diagnosing any condition, and shouldn't replace talking to a certified medical or healthcare professional.

Reviewer

Dr. Aman Priya Khanna

Dr. Aman Priya Khanna

MBBS, DNB General Surgery, Fellowship in Minimal Access Surgery, FIAGES

12 Years Experience

Dr Aman Priya Khanna is a well-known General Surgeon, Proctologist and Bariatric Surgeon currently associated with HealthFort Clinic, Health First Multispecialty Clinic in Delhi. He has 12 years of experience in General Surgery and worke...View More

Author

Rajath R Prabhu

Rajath R Prabhu

MSc. Clinical Research I PG Diploma in Public Health Services Management

3 Years Experience

His work in medical content writing and proofreading is noteworthy. He has also contributed immensely to public health research and has authored four scientific manuscripts in international journals. He was assoc...View More

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